The developers of TinyMCE brings you Plupload, a highly usable upload handler for your Content Management Systems or similar. Plupload is currently separated into a Core API and a jQuery upload queue widget this enables you to either use it out of the box or write your own custom implementation.
This looks pretty nice, I wonder how hard it would be to make my own drop.io kinda deal.
via Plupload – A tool for uploading files using Flash, Silverlight, Google Gears, HTML5 or Browserplus.